Professional Profile
Early Academic Pursuits
Song Guo Zheng embarked on his academic journey with an MD from Anhui Medical University followed by an MS from Fudan University Shanghai School of Medicine and eventually earned his PhD from the University of Orleans in France. These foundational educational pursuits laid the groundwork for his distinguished career.
Professional Endeavors
His professional journey spans over four decades, showcasing a progressive trajectory marked by pivotal roles at esteemed institutions globally. Noteworthy positions include his tenure as the Ronald L. Whisler Chair in Rheumatology and Immunology at the Ohio State University School of Medicine, along with significant roles at the Pennsylvania State University Hershey Medical Center and the University of Southern California Keck School of Medicine.
Contributions and Research Focus
As a pioneer in immunology, Dr. Zheng's contributions are profound. Notably, his discovery of induced regulatory T cells and extensive work on Gingival Mesenchymal Stem Cells in autoimmune diseases have reshaped the landscape of immunotherapy. His studies on immune regulatory T cells, mechanisms of induction, and identification of various subsets have significantly influenced the understanding and treatment of autoimmune conditions.
Accolades and Recognition
His exceptional contributions have garnered widespread acclaim, evident through numerous prestigious awards such as the Freda Newton Memorial Scholar Award, ACR Investigator Award, NIH Star Award, and more. His impressive publication record, with an H-index of 74 and over 210 publications, solidifies his standing as a leading expert in rheumatology, immunology, allergy, and inflammatory diseases.
Impact and Influence
His impact resonates through his pivotal discoveries in immune regulation and innovative approaches in treating inflammatory diseases. His findings on Treg cell therapy, retinoic acid's role in Treg amplification, and identifying novel targets for inhibiting inflammatory diseases showcase his far-reaching influence on the field.
Legacy and Future Contributions
His legacy stands as a testament to groundbreaking research, innovative treatments, and a commitment to advancing autoimmune disease therapeutics. His future contributions are anticipated to further revolutionize immunotherapy, leveraging novel findings and continued dedication to unraveling the complexities of immune regulation and inflammatory diseases.
Notable Publications
Natural and induced CD4+ CD25+ cells educate CD4+ CD25− cells to develop suppressive activity: the role of IL-2, TGF-β, and IL-10
SG Zheng, JH Wang, JD Gray, H Soucier, DA Horwitz
( 920 )2004
IL-2 is essential for TGF-β to convert naive CD4+ CD25− cells to CD25+ Foxp3+ regulatory T cells and for expansion of these cells
SG Zheng, J Wang, P Wang, JD Gray, DA Horwitz
( 775 )2007
Generation ex vivo of TGF-β-producing regulatory T cells from CD4+ CD25− precursors
SG Zheng, JD Gray, K Ohtsuka, S Yamagiwa, DA Horwitz
( 588 )2002
Role of vitamin A in the immune system
Z Huang, Y Liu, G Qi, D Brand, SG Zheng
( 571 )2018
TGF-β requires CTLA-4 early after T cell activation to induce FoxP3 and generate adaptive CD4+ CD25+ regulatory cells
SG Zheng, JH Wang, W Stohl, KS Kim, JD Gray, DA Horwitz
( 472 )2006
Natural and TGF-β–induced Foxp3+ CD4+ CD25+ regulatory T cells are not mirror images of each other
DA Horwitz, SG Zheng, JD Gray
Role of TNF–TNF receptor 2 signal in regulatory T cells and its therapeutic implications
S Yang, J Wang, DD Brand, SG Zheng
( 324 )2018
The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3
Z Chen, J Barbi, S Bu, HY Yang, Z Li, Y Gao, D Jinasena, J Fu, F Lin, ...
( 308 )2013
The role of the combination of IL-2 and TGF-β or IL-10 in the generation and function of CD4+ CD25+ and CD8+regulatory T cell subsets
DA Horwitz, SG Zheng, JD Gray
( 303 )2003
CD4+ and CD8+ regulatory T cells generated ex vivo with IL-2 and TGF-β suppress a stimulatory graft-versus-host disease with a lupus-like syndrome
SG Zheng, JH Wang, MN Koss, F Quismorio, JD Gray, DA Horwitz
( 285 )2004
Hall of fame among pro-inflammatory cytokines: interleukin-6 gene and its transcriptional regulation mechanisms
Y Luo, SG Zheng
( 282 )2016
Cutting edge: all-trans retinoic acid sustains the stability and function of natural regulatory T cells in an inflammatory milieu
X Zhou, N Kong, J Wang, H Fan, H Zou, D Horwitz, D Brand, Z Liu, ...
( 260 )2010
Citations
A total of 1646 citations for his publications, demonstrating the impact and recognition of his research within the academic community.
- Citations 17730 10684
- h-index 75 58
- i10-index 187 177