Prof. Jianhua Ju | Natural Medicinal Chemistry | Best Researcher Award

Professor at South China Sea Institute of Oceanology of the Chinese Academy of Sciences, China

Professor Jianhua Ju is a distinguished researcher at the South China Sea Institute of Oceanology, Chinese Academy of Sciences. His expertise lies in the discovery of bioactive secondary metabolites from microorganisms in extreme environments, as well as in the fields of synthetic biology, metabolic engineering, and anti-infective and anti-tumor drug development.

Profile:

• Scopus
• Orcid

🧪 Academic & Research Focus:

Professor Ju is a pioneering researcher specializing in:

• 🌊 Marine and Desert Microorganisms – Discovery of novel bioactive secondary metabolites

• 🧬 Synthetic Biology & Biosynthesis – Combinatorial biosynthesis and metabolic engineering

• 💊 Drug Discovery – Focused on anti-infective and anti-tumor therapeutic compounds

📊 Research Excellence:

• 📚 248 SCI/Scopus-indexed publications

• 📈 7,946 citations across 5,812 documents 📎 Scopus Profile

• 🔬 Led 20+ major research projects (incl. National Key R&D, 863 Program)

• 🧪 Discovered 1,000+ active natural compounds

• 🧪 Clarified 20+ biosynthesis mechanisms and 30+ novel enzymes

• 💉 Developed 3 drug candidates (1 in preclinical phase)

📘 Innovation & Impact:

• 🛠️ 72 patents filed/published

• 🏢 Collaborations with industry (e.g., Syngenta Ph.D. Fellowship Program)

• 🏥 Partnerships with clinical institutions for translational research

📰 Editorial and Academic Leadership:

• ✍️ Executive Editor-in-Chief – Pharmaceutical Science Advances

• 🧪 Editorial Boards – Journal of Natural Products, Marine Drugs, and more

• 🎓 Vice Chairman – Marine Drugs Committee, Chinese Pharmaceutical Association

• 🧫 Vice Chairman – Marine Microbiology Committee, Chinese Society for Microbiology

🏅 Recognition & Memberships:

• Recipient of multiple national-level research awards

• Hosted high-impact projects including National Science Fund for Distinguished Young Scholars

📊 Citation Metrics (as per Scopus):

• Total Citations: 7,946

• Citing Documents: 5,812

• Total Publications: 224

• h-index: 45

Publication Top Notes:

1. Enzymatic Insights into the Unusual Formation of Benzolactone and Benzopyran in the Biosynthesis of Spiromarmycin
   Chen, Y., Jing, L., Peng, M., Cai, C., Shi, J., Ge, W., Liu, Y., Shang, Z., Ma, J., Wu, D., Ju, J. et al.
   ACS Catalysis, 2025-02-21. DOI: 10.1021/acscatal.4c07664
   ISSN: 2155-5435

2. Antarmycins: Discovery, Biosynthesis, Anti-pathogenic Bacterial Activity, and Mechanism of Action from Deep-Sea-Derived Pseudonocardia antarctica
   Zhou, Z., Yang, J., Ma, J., Shang, Z., Fang, R., Tian, X., Li, Q., Ju, J.
   JACS Au, 2025-01-27. DOI: 10.1021/jacsau.4c00912
   ISSN: 2691-3704

3. Metabolic Blockade-Based Genome Mining of Malbranchea circinata SDU050: Discovery of Diverse Secondary Metabolites
   Yang, H., Luo, X., Shang, Z., Li, K., Cai, J., Chen, Y., Xin, L., Ju, J.
   Marine Drugs, 2025-01-20. DOI: 10.3390/md23010050
   ISSN: 1660-3397

4. Metabolic Blockade-Based Genome Mining of Saccharopolyspora erythraea SCSIO 07745: Discovery and Biosynthetic Pathway of Aminoquinolinone Alkaloids Bearing 6/6/5 Tricyclic and 6/6/6/5 Tetracyclic Scaffolds
   Li, K., Zhu, H., Sun, C., Tian, G., Ma, X., Kumar, P.S., Weng, X., Yang, H., Fang, R., Liu, W., Ju, J. et al.
   Organic Letters, 2025-01-10. DOI: 10.1021/acs.orglett.4c04491
   ISSN: 1523-7060

5. β-Terrecyclene Synthase Constructs the Quadrane Backbone in Terrecyclic Acid Biosynthesis
   Song, Y., Wang, W., Yang, J., Gao, D.-W., Billingsley, J.M., Wang, S., Zhu, Y., Wang, J., Ju, J., Yan, Y. et al.
   Chemical Science, 2024. DOI: 10.1039/d4sc01208a
   ISSN: 2041-6520

6. Bacterial Biosynthesis of Nitrile-Containing Natural Products: Basis for Recognition of Diversified Substrates
   Peng, M., Wu, Q., Ma, L., Teng, Z.-J., Hou, X., Zhu, H., Ju, J.
   ACS Catalysis, 2024-12-06. DOI: 10.1021/acscatal.4c06581
   ISSN: 2155-5435

7. Two Disaccharide-Bearing Polyethers, K-41B and K-41Bm, Potently Inhibit HIV-1 via Mechanisms Different from That of Their Precursor Polyether, K-41A
   Liu, J., Wei, Q., Liu, X., Chen, J., Zhan, Y., Li, Q., Wang, Q., Liang, B., Jiang, J., Qin, F., Ju, J. et al.
   Current Issues in Molecular Biology, 2024-11-25. DOI: 10.3390/cimb46120805
   ISSN: 1467-3045

8. Flavin-Dependent Monooxygenase Kmy13 Mediates Formation of the Carbocyclic Ansa System during Kendomycin B Biosynthesis
   Chen, J., Zhu, H., Peng, M., Zhang, S., Li, Q., Gu, Y.-C., Ju, J.
   Journal of the American Chemical Society, 2024-10-06. DOI: 10.1021/jacs.4c08774
   ISSN: 0002-7863